Evaluation of coxsackievirus and adenovirus receptor expression in human benign and malignant thyroid lesions

Giaginis, C., Zarros, A. , Alexandrou, P., Klijanienko, J., Delladetsima, I. and Theocharis, S. (2010) Evaluation of coxsackievirus and adenovirus receptor expression in human benign and malignant thyroid lesions. APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica, 118(3), pp. 210-221. (doi: 10.1111/j.1600-0463.2009.02582.x) (PMID:20132187)

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Abstract

Coxsackievirus and adenovirus receptor (CAR) expression on tumor cells is associated with sensitivity to adenoviral infection, being considered as a surrogate marker for monitoring and/or predicting adenovirus-mediated gene therapy. The aim of this study was to evaluate the clinical significance of CAR expression in human benign and malignant thyroid lesions. CAR protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 107 patients with benign and malignant lesions and was statistically analyzed in relation to histopathologic type; tumor size; lymph node metastasis; capsular, lymphatic and vessel invasion; as well as follicular cells' proliferative capacity. CAR immunoreactivity was characterized as negative/weak in 53 (49.53%), moderate in 31 (28.97%) and strong in 23 (21.50%) of 107 thyroid cases. CAR immunoreactivity was significantly increased in malignant compared with that in benign thyroid lesions (p = 0.00002). Both malignant and benign thyroid lesions with enhanced follicular cells' proliferative capacity showed significantly increased CAR immunoreactivity (p = 0.00027). In malignant thyroid lesions, enhanced CAR immunoreactivity was significantly associated with larger tumor size (p = 0.0067). The current data revealed that CAR immunoreactivity could be considered of diagnostic utility in thyroid neoplasia. Further research effort is warranted to delineate whether CAR could be considered clinically important for both diagnosis and future (gene) therapeutic applications in thyroid neoplasia.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Zarros, Dr Apostolos
Authors: Giaginis, C., Zarros, A., Alexandrou, P., Klijanienko, J., Delladetsima, I., and Theocharis, S.
Subjects:R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RZ Other systems of medicine
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Journal Abbr.:APMIS
ISSN:0903-4641
ISSN (Online):1600-0463
Published Online:01 February 2010

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