Intracerebroventricular administration of streptozotocin as an experimental approach to Alzheimer's disease

Kalafatakis, K. and Zarros, A. (2014) Intracerebroventricular administration of streptozotocin as an experimental approach to Alzheimer's disease. International Journal of Neuroscience, 124(12), pp. 944-946. (doi: 10.3109/00207454.2014.890934) (PMID:24494726)

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Abstract

The in vivo experimental simulation of Alzheimer's disease (AD) has been a field of paramount importance for Experimental Medicine and Neuroscience for more than 20 years. We herein provide a short overview of an experimental approach to sporadic AD that is based on the insulin-resistant state induced in the brains of animals following the intracerebroventricular (icv) administration of streptozotocin (STZ) at low doses. The icv administration of STZ is considered as an established, standardized and reproducible approach to sporadic AD, central aspects of the pathology of which it can reliably simulate.

Item Type:Articles (Letter)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Zarros, Dr Apostolos
Authors: Kalafatakis, K., and Zarros, A.
Subjects:R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:International Journal of Neuroscience
Publisher:Informa Healthcare
ISSN:0020-7454
ISSN (Online):1563-5279
Published Online:12 March 2014

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