Tuning the endocytosis mechanism of Zr-based metal−organic frameworks through linker functionalization

Orellana-Tavra, C., Haddad, S., Marshall, R. J., Abánades Lázaro, I., Boix, G., Imaz, I., Maspoch, D., Forgan, R. S. and Fairen-Jimenez, D. (2017) Tuning the endocytosis mechanism of Zr-based metal−organic frameworks through linker functionalization. ACS Applied Materials and Interfaces, 9(41), pp. 35516-35525. (doi: 10.1021/acsami.7b07342) (PMID:28925254)

Abstract

A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an effi-cient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4'-biphenyldicarboxylic acid ligands promote entry through the caveolin-pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol, en-hancing their therapeutic activity when loaded with drugs.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Abanades, Isabel and Forgan, Professor Ross and Marshall, Mr Ross James
• Authors: Orellana-Tavra, C., Haddad, S., Marshall, R. J., Abánades Lázaro, I., Boix, G., Imaz, I., Maspoch, D., Forgan, R. S., and Fairen-Jimenez, D.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: ACS Applied Materials and Interfaces
• Publisher: American Chemical Society
• ISSN: 1944-8244
• ISSN (Online): 1944-8252
• Published Online: 19 September 2017
• Copyright Holders: Copyright © 2017 American Chemical Society
• First Published: First published in ACS Applied Materials and Interfaces 9(41):35516–35525
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
61947	1	Biomimetic guest selective metal-organic frameworks: catalysis and self-assembly	Ross Forgan	Engineering and Physical Sciences Research Council (EPSRC)	EP/L004461/1	CHEM - CHEMISTRY