Tuning the endocytosis mechanism of Zr-based metal−organic frameworks through linker functionalization

Orellana-Tavra, C., Haddad, S., Marshall, R. J., Abánades Lázaro, I., Boix, G., Imaz, I., Maspoch, D., Forgan, R. S. and Fairen-Jimenez, D. (2017) Tuning the endocytosis mechanism of Zr-based metal−organic frameworks through linker functionalization. ACS Applied Materials and Interfaces, 9(41), pp. 35516-35525. (doi:10.1021/acsami.7b07342) (PMID:28925254)

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Abstract

A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an effi-cient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4'-biphenyldicarboxylic acid ligands promote entry through the caveolin-pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol, en-hancing their therapeutic activity when loaded with drugs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Abanades, Isabel and Forgan, Dr Ross and Marshall, Mr Ross James
Authors: Orellana-Tavra, C., Haddad, S., Marshall, R. J., Abánades Lázaro, I., Boix, G., Imaz, I., Maspoch, D., Forgan, R. S., and Fairen-Jimenez, D.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:ACS Applied Materials and Interfaces
Publisher:American Chemical Society
ISSN:1944-8244
ISSN (Online):1944-8252
Published Online:19 September 2017
Copyright Holders:Copyright © 2017 American Chemical Society
First Published:First published in ACS Applied Materials and Interfaces 9(41):35516–35525
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
619471Biomimetic guest selective metal-organic frameworks: catalysis and self-assemblyRoss ForganEngineering and Physical Sciences Research Council (EPSRC)EP/L004461/1CHEM - CHEMISTRY