A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog

Atherton, M. J., Vazquez-Sanmartin, S., Sharpe, S., Waugh, E. M. and Morris, J. S. (2017) A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog. Veterinary Clinical Pathology, 46(3), pp. 520-525. (doi:10.1111/vcp.12503) (PMID:28582596)

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Abstract

A 10-year-old crossbred dog was presented with a 6-week history of hematemesis, melena, anorexia, and lethargy. Clinical evaluation revealed a gastric mass with a regional lymphadenomegaly as well as a monoclonal gammopathy manifesting as hyperglobulinemia. Cytologic and histopathologic analyses were consistent with a round cell neoplasm; neoplastic cells showed nuclear immunoreactivity for MUM1 and diffuse cytoplasmic reactivity for CD3. Polymerase chain reactions performed on fixed and fresh tissue identified a clonal rearrangement with an IgH primer set. An extramedullary plasmacytoma (EMP) was confirmed by cellular morphology and molecular diagnostics. Following an objective response to chemotherapy, the dog was euthanized 8 months after diagnosis, and a postmortem examination confirmed the clinical findings. This is the first reported case of a monoclonal gammopathy secondary to a gastric EMP coupled with aberrant expression of CD3 in an aggressive plasmacytic tumor, and highlights the utility of molecular diagnostics for classifying atypical hemolymphoid neoplasms.

Item Type:Articles
Keywords:General Veterinary
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morris, Professor Joanna and Waugh, Ms Elspeth
Authors: Atherton, M. J., Vazquez-Sanmartin, S., Sharpe, S., Waugh, E. M., and Morris, J. S.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Clinical Pathology
Publisher:Wiley
ISSN:0275-6382
ISSN (Online):1939-165X
Published Online:05 June 2017
Copyright Holders:Copyright © 2017 American Society for Veterinary Clinical Pathology
First Published:First published in Veterinary Clinical Pathology 46(3):520-525
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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