Atherton, M. J., Vazquez-Sanmartin, S., Sharpe, S., Waugh, E. M. and Morris, J. S. (2017) A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog. Veterinary Clinical Pathology, 46(3), pp. 520-525. (doi: 10.1111/vcp.12503) (PMID:28582596)
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Abstract
A 10-year-old crossbred dog was presented with a 6-week history of hematemesis, melena, anorexia, and lethargy. Clinical evaluation revealed a gastric mass with a regional lymphadenomegaly as well as a monoclonal gammopathy manifesting as hyperglobulinemia. Cytologic and histopathologic analyses were consistent with a round cell neoplasm; neoplastic cells showed nuclear immunoreactivity for MUM1 and diffuse cytoplasmic reactivity for CD3. Polymerase chain reactions performed on fixed and fresh tissue identified a clonal rearrangement with an IgH primer set. An extramedullary plasmacytoma (EMP) was confirmed by cellular morphology and molecular diagnostics. Following an objective response to chemotherapy, the dog was euthanized 8 months after diagnosis, and a postmortem examination confirmed the clinical findings. This is the first reported case of a monoclonal gammopathy secondary to a gastric EMP coupled with aberrant expression of CD3 in an aggressive plasmacytic tumor, and highlights the utility of molecular diagnostics for classifying atypical hemolymphoid neoplasms.
Item Type: | Articles |
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Keywords: | General Veterinary |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Morris, Professor Joanna and Waugh, Ms Elspeth |
Authors: | Atherton, M. J., Vazquez-Sanmartin, S., Sharpe, S., Waugh, E. M., and Morris, J. S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Veterinary Clinical Pathology |
Publisher: | Wiley |
ISSN: | 0275-6382 |
ISSN (Online): | 1939-165X |
Published Online: | 05 June 2017 |
Copyright Holders: | Copyright © 2017 American Society for Veterinary Clinical Pathology |
First Published: | First published in Veterinary Clinical Pathology 46(3):520-525 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
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