Redpath, S. A., Heieis, G. A., Reynolds, L. A., Fonseca, N. M., Kim, S. S.-Y. and Perona-Wright, G. (2018) Functional specialization of intestinal dendritic cell subsets during Th2 helminth infection in mice. European Journal of Immunology, 48(1), pp. 87-98. (doi: 10.1002/eji.201747073) (PMID:28960280)
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Abstract
Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that different intestinal DC subsets are involved in the induction of T helper (Th)17 and regulatory T cell responses, but the cells that initiate Th2 immune responses are still incompletely understood. We show that in the Th2 response to an intestinal helminth in mice, only CD11b+ and not CD11b− DCs accumulate in the local lymph node, upregulate PDL2 and express markers of alternative activation. An enteric Th1 response instead activated both CD11b+ and CD11b− DCs without eliciting alternative activation in either population. Functionally, only CD11b+ DCs activated during helminth infection supported Th2 differentiation in naive CD4+ T cells. Together our data demonstrate that the ability to prime Th2 cells during intestinal helminth infection, is a selective and inducible characteristic of CD11b+ DCs.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Heieis, Graham Anthony and Perona-Wright, Dr Georgia |
| Authors: | Redpath, S. A., Heieis, G. A., Reynolds, L. A., Fonseca, N. M., Kim, S. S.-Y., and Perona-Wright, G. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | European Journal of Immunology |
| Publisher: | Wiley |
| ISSN: | 0014-2980 |
| ISSN (Online): | 1521-4141 |
| Published Online: | 27 September 2017 |
| Copyright Holders: | Copyright © 2017 Wiley-VCH Verlag GmbH & Co. |
| First Published: | First published in European Journal of Immunology 48(1): 87-98 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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