pfk13 -Independent treatment failure in four imported cases of Plasmodium falciparum malaria treated with artemether-lumefantrine in the United Kingdom

Sutherland, C. J. et al. (2017) pfk13 -Independent treatment failure in four imported cases of Plasmodium falciparum malaria treated with artemether-lumefantrine in the United Kingdom. Antimicrobial Agents and Chemotherapy, 61(3), -16. e02382. (doi: 10.1128/aac.02382-16) (PMID:28137810) (PMCID:PMC5328508)

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Abstract

We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.

Item Type:Articles
Additional Information:P.L.C. is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. All of us declare that we have no conflicting interests. This work was supported by funding from Public Health England to the Malaria Reference Laboratory at LSHTM. Genome sequencing was funded by Wellcome Trust grant WT089051 to the Sanger Institute.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Otto, Dr Thomas
Authors: Sutherland, C. J., Lansdell, P., Sanders, M., Muwanguzi, J., van Schalkwyk, D. A., Kaur, H., Nolder, D., Tucker, J., Bennett, H. M., Otto, T. D., Berriman, M., Patel, T. A., Lynn, R., Gkrania-Klotsas, E., and Chiodini, P. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Antimicrobial Agents and Chemotherapy
Publisher:American Association for Microbiology
ISSN:0066-4804
ISSN (Online):1098-6596
Copyright Holders:Copyright © 2017 Sutherland et al
First Published:First published in Antimicrobial Agents and Chemotherapy 61(3):e02382
Publisher Policy:Reproduced under a Creative Commons License

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