The chronic and evolving neurological consequences of traumatic brain injury

Wilson, L., Stewart, W. , Dams-O'Connor, K., Diaz-Arrastia, R., Horton, L., Menon, D. K. and Polinder, S. (2017) The chronic and evolving neurological consequences of traumatic brain injury. Lancet Neurology, 16(10), pp. 813-825. (doi:10.1016/S1474-4422(17)30279-X)

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Abstract

Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology, which includes chronic traumatic encephalopathy. Despite growing awareness of the lifelong consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stewart, Dr William
Authors: Wilson, L., Stewart, W., Dams-O'Connor, K., Diaz-Arrastia, R., Horton, L., Menon, D. K., and Polinder, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Lancet Neurology
Publisher:The Lancet Publishing Group
ISSN:1474-4422
ISSN (Online):1474-4465
Published Online:12 September 2017
Copyright Holders:Copyright © 2017 Elsevier Ltd.
First Published:First published in Lancet Neurology 16(10): 813-825
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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