Genomic analysis of the causative agents of coccidiosis in domestic chickens

Reid, A. J. et al. (2014) Genomic analysis of the causative agents of coccidiosis in domestic chickens. Genome Research, 24(10), pp. 1676-1685. (doi: 10.1101/gr.168955.113) (PMID:25015382) (PMCID:PMC4199364)

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Abstract

Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Otto, Dr Thomas
Authors: Reid, A. J., Blake, D. P., Ansari, H. R., Billington, K., Browne, H. P., Bryant, J., Dunn, M., Hung, S. S., Kawahara, F., Miranda-Saavedra, D., Malas, T. B., Mourier, T., Naghra, H., Nair, M., Otto, T. D., Rawlings, N. D., Rivailler, P., Sanchez-Flores, A., Sanders, M., Subramaniam, C., Tay, Y.-L., Woo, Y., Wu, X., Barrell, B., Dear, P. H., Doerig, C., Gruber, A., Ivens, A. C., Parkinson, J., Rajandream, M.-A., Shirley, M. W., Wan, K.-L., Berriman, M., Tomley, F. M., and Pain, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Genome Research
Publisher:Cold Spring Harbor Laboratory Press
ISSN:1088-9051
ISSN (Online):1549-5469
Published Online:11 July 2014
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Genome Research 24(10): 1676-1685
Publisher Policy:Reproduced under a Creative Commons License

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