Translational Trial Outcomes for Capsule Endoscopy Test Devices

Lay, H. S. et al. (2017) Translational Trial Outcomes for Capsule Endoscopy Test Devices. In: 2017 IEEE International Ultrasonics Symposium (IUS), Washington, D.C., USA, 6-9 Sept 2017, ISBN 978138633830 (doi:10.1109/ULTSYM.2017.8091826)

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Abstract

Current clinical standards in the endoscopic diagnosis of gastrointestinal diseases are primarily based on the use of optical systems. Ultrasound has established diagnostic credibility in the form of endoscopic ultrasound (EUS), however it is limited to examination of the upper gastrointestinal tract (oesophagus, stomach and upper (proximal) small bowel). Access to the remainder of the small bowel is currently limited to optical capsule endoscopes and a limited number of other modalities as these capsules are restricted to visual examination of the surface or mucosa of the gut wall. Ultrasound capsule endoscopy has been proposed to integrate microultrasound imaging capabilities into the existing capsule format and extend examination capabilities beyond the mucosa. To establish the ability of high frequency ultrasound to resolve the histological structure of the gastrointestinal tract, ex vivo scans of pig and human tissue were performed. This was done using 25 and 34 MHz single element, physically focused composite transducers mechanically scanned along the tissue. Tethered prototype devices were then developed with 30 MHz physically focused polyvinylidene fluoride (PVDF) single element transducers embedded for use in initial translational trials in the small bowel of porcine subjects. B-scan images from the ex vivo model validation and the in vivo trials are presented.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Seetohul, Dr Vipin and Turcanu, Mihnea and Qiu, Dr Yongqiang and Connor, Mr Ciaran and Cochran, Professor Alexander and Lay, Dr Holly and McPhillips, Miss Rachael
Authors: Lay, H. S., Cummins, G., Cox, B. F., Qiu, Y., Connor, C., Seetohul, V., Turcanu, M., McPhillips, R., Desmulliez, M. P.Y., Clutton, E., and Cochran, S.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
ISSN:1948-5727
ISBN:978138633830
Copyright Holders:Copyright © 2017 IEEE
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
615381Sonopill: minimally invasive gastrointestinal diagnosis and therapyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/1ENG - ENGINEERING ELECTRONICS & NANO ENG
748241Sonopill: minimally invasive gastrointestinal diagnosis and therapyAlexander CochranEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/2ENG - ENGINEERING SYSTEMS POWER & ENERGY