da Silva, M. S., Pavani, R. S., Damasceno, J. D. , Marques, C. A. , McCulloch, R. , Tosi, L. R. O. and Elias, M. C. (2017) Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems. Trends in Parasitology, 33(11), pp. 858-874. (doi: 10.1016/j.pt.2017.08.002) (PMID:28844718) (PMCID:PMC5662062)
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Abstract
In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments. However, these parasites encode several replication protein components and complexes that show potentially variant composition compared with model eukaryotes. This review focuses on the advances made in recent years regarding the differences and peculiarities of the replication machinery in trypanosomatids, including how such divergence might affect DNA replication dynamics and the replication stress response. Comparing the DNA replication machinery and processes of parasites and their hosts may provide a foundation for the identification of targets that can be used in the development of chemotherapies to assist in the eradication of diseases caused by these pathogens.
Item Type: | Articles |
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Keywords: | DNA replication, origin recognition complex, replication fork, replication origins, replication stress, trypanosomatid emergence. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Damasceno, Dr Jeziel and McCulloch, Professor Richard and De Almeida Marques, Dr Catarina |
Authors: | da Silva, M. S., Pavani, R. S., Damasceno, J. D., Marques, C. A., McCulloch, R., Tosi, L. R. O., and Elias, M. C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Trends in Parasitology |
Publisher: | Elsevier (Cell Press) |
ISSN: | 1471-4922 |
ISSN (Online): | 1471-5007 |
Published Online: | 24 August 2017 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Trends in Parasitology 33(11): 858-874 |
Publisher Policy: | Reproduced under a Creative Commons License |
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