Chirita-Emandi, A., Shepherd, S., Kyriakou, A., McNeilly, J. D., Dryden, C., Corrigan, D., Devenny, A. and Ahmed, S. F. (2017) A retrospective analysis of longitudinal changes in bone mineral content in cystic fibrosis. Journal of Pediatric Endocrinology and Metabolism, 30(8), pp. 807-814. (doi: 10.1515/jpem-2016-0057) (PMID:28222031)
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Abstract
Background: We aimed to describe the longitudinal changes in bone mineral content and influencing factors, in children with cystic fibrosis (CF). Methods: One hundred children (50 females) had dual X-ray absorptiometry (DXA) performed. Of these, 48 and 24 children had two to three scans, respectively over 10 years of follow-up. DXA data were expressed as lumbar spine bone mineral content standard deviation score (LSBMCSDS) adjusted for age, gender, ethnicity and bone area. Markers of disease, anthropometry and bone biochemistry were collected retrospectively. Results: Baseline LSBMCSDS was >0.5 SDS in 13% children, between −0.5; 0.5 SDS, in 50% and ≤−0.5 in the remainder. Seventy-eight percent of the children who had baseline LSBMCSDS >−0.5, and 35% of the children with poor baseline (LSBMCSDS<−0.5), showed decreasing values in subsequent assessments. However, mean LS BMC SDS did not show a significant decline in subsequent assessments (−0.51; −0.64; −0.56; p=0.178). Lower forced expiratory volume in 1 s percent (FEV1%) low body mass index standard deviation scores (BMI SDS) and vitamin D were associated with reduction in BMC. Conclusions: Bone mineral content as assessed by DXA is sub-optimal and decreases with time in most children with CF and this study has highlighted parameters that can be addressed to improve bone health.
Item Type: | Articles |
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Additional Information: | Adela Chirita-Emandi was supported by the European Society of Paediatric Endocrinology through a Clinical Fellowship. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Shepherd, Dr Sheila and Devenny, Dr Anne and Mcneilly, Dr Jane and Kyriakou, Dr Andreas and Chirita-Emandi, Dr Adela and Ahmed, Professor Syed Faisal |
Authors: | Chirita-Emandi, A., Shepherd, S., Kyriakou, A., McNeilly, J. D., Dryden, C., Corrigan, D., Devenny, A., and Ahmed, S. F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Journal of Pediatric Endocrinology and Metabolism |
Publisher: | De Gruyter |
ISSN: | 0334-018X |
ISSN (Online): | 2191-0251 |
Published Online: | 21 February 2017 |
Copyright Holders: | Copyright © 2017 Walter de Gruyter GmbH |
First Published: | First published in Journal of Pediatric Endocrinology and Metabolism 30(8): 807-814 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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