Gracia-Lor, E. et al. (2017) Estimation of caffeine intake from analysis of caffeine metabolites in wastewater. Science of the Total Environment, 609, pp. 1582-1588. (doi: 10.1016/j.scitotenv.2017.07.258) (PMID:28810510)
|
Text
146675.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 682kB | |
|
Text
146675Suppl.pdf - Supplemental Material 726kB |
Abstract
Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use.
| Item Type: | Articles |
|---|---|
| Keywords: | 1,7-dimethyluric acid, back-calculation, caffeine, correction factor, urinary biomarkers, wastewater-based epidemiology. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Yang, Dr Zhugen |
| Authors: | Gracia-Lor, E., Rousis, N. I., Zuccato, E., Bade, R., Baz-Lomba, J. A., Castrignanò, E., Causanilles, A., Hernández, F., Kasprzyk-Hordern, B., Kinyua, J., McCall, A.-K., van Nuijs, A. L. N., Plósz, B. G., Ramin, P., Ryu, Y., Santos, M. M., Thomas, K., de Voogt, P., Yang, Z., and Castiglioni, S. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Science of the Total Environment |
| Publisher: | Elsevier |
| ISSN: | 0048-9697 |
| ISSN (Online): | 1879-1026 |
| Published Online: | 08 August 2017 |
| Copyright Holders: | Copyright © 2017 Elsevier B.V. |
| First Published: | First published in Science of the Total Environment 609: 1582-1588 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric