Estimation of caffeine intake from analysis of caffeine metabolites in wastewater

Gracia-Lor, E. et al. (2017) Estimation of caffeine intake from analysis of caffeine metabolites in wastewater. Science of the Total Environment, 609, pp. 1582-1588. (doi:10.1016/j.scitotenv.2017.07.258) (PMID:28810510)

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Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use.

Item Type:Articles
Keywords:1,7-dimethyluric acid, back-calculation, caffeine, correction factor, urinary biomarkers, wastewater-based epidemiology.
Glasgow Author(s) Enlighten ID:Yang, Dr Zhugen
Authors: Gracia-Lor, E., Rousis, N. I., Zuccato, E., Bade, R., Baz-Lomba, J. A., Castrignanò, E., Causanilles, A., Hernández, F., Kasprzyk-Hordern, B., Kinyua, J., McCall, A.-K., van Nuijs, A. L. N., Plósz, B. G., Ramin, P., Ryu, Y., Santos, M. M., Thomas, K., de Voogt, P., Yang, Z., and Castiglioni, S.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Science of the Total Environment
ISSN (Online):1879-1026
Published Online:08 August 2017
Copyright Holders:Copyright © 2017 Elsevier B.V.
First Published:First published in Science of the Total Environment 609: 1582-1588
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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