A 16 x 16 CMOS amperometric microelectrode array for simultaneous electrochemical measurements

Giagkoulovits, C. , Cheah, B. C. , Al-Rawhani, M. A., Accarino, C., Busche, C., Grant, J. P. and Cumming, D. R.S. (2018) A 16 x 16 CMOS amperometric microelectrode array for simultaneous electrochemical measurements. IEEE Transactions on Circuits and Systems I: Regular Papers, 65(9), pp. 2821-2831. (doi:10.1109/TCSI.2018.2794502)

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Abstract

There is a requirement for an electrochemical sensor technology capable of making multivariate measurements in environmental, healthcare, and manufacturing applications. Here, we present a new device that is highly parallelized with an excellent bandwidth. For the first time, electrochemical cross-talk for a chip-based sensor is defined and characterized. The new CMOS electrochemical sensor chip is capable of simultaneously taking multiple, independent electroanalytical measurements. The chip is structured as an electrochemical cell microarray, comprised of a microelectrode array connected to embedded self-contained potentiostats. Speed and sensitivity are essential in dynamic variable electrochemical systems. Owing to the parallel function of the system, rapid data collection is possible while maintaining an appropriately low-scan rate. By performing multiple, simultaneous cyclic voltammetry scans in each of the electrochemical cells on the chip surface, we are able to show (with a cell-to-cell pitch of 456 μm) that the signal cross-talk is only 12% between nearest neighbors in a ferrocene rich solution. The system opens up the possibility to use multiple independently controlled electrochemical sensors on a single chip for applications in DNA sensing, medical diagnostics, environmental sensing, the food industry, neuronal sensing, and drug discovery.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cumming, Professor David and Busche, Dr Christoph and Al-Rawhani, Dr Mohammed and Accarino, Claudio and Giagkoulovits, Mr Christos and Cheah, Dr Boon Chong and Grant, Dr James
Authors: Giagkoulovits, C., Cheah, B. C., Al-Rawhani, M. A., Accarino, C., Busche, C., Grant, J. P., and Cumming, D. R.S.
College/School:College of Science and Engineering > School of Chemistry
College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:IEEE Transactions on Circuits and Systems I: Regular Papers
Publisher:IEEE
ISSN:1549-8328
ISSN (Online):1558-0806
Published Online:06 February 2018
Copyright Holders:Copyright © 2018 IEEE
First Published:First published in IEEE Transactions on Circuits and Systems I: Regular Papers 2018
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.5525/gla.researchdata.437

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
605821The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - ENGINEERING ELECTRONICS & NANO ENG