Keratinocyte differentiation-dependent human papillomavirus gene regulation

Graham, S. V. (2017) Keratinocyte differentiation-dependent human papillomavirus gene regulation. Viruses, 9(9), 245. (doi: 10.3390/v9090245) (PMID:28867768) (PMCID:PMC5618011)

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Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte. The normal replication cycle involves an early and a late phase. The early phase encompasses viral entry and initial genome replication, stimulation of cell division and inhibition of apoptosis in the infected cell. Late events in the HPV life cycle include viral genome amplification, virion formation, and release into the environment from the surface of the epithelium. The main proteins required at the late stage of infection for viral genome amplification include E1, E2, E4 and E5. The late proteins L1 and L2 are structural proteins that form the viral capsid. Regulation of these late events involves both cellular and viral proteins. The late viral mRNAs are expressed from a specific late promoter but final late mRNA levels in the infected cell are controlled by splicing, polyadenylation, nuclear export and RNA stability. Viral late protein expression is also controlled at the level of translation. This review will discuss current knowledge of how HPV late gene expression is regulated.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Graham, Professor Sheila
Authors: Graham, S. V.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Viruses
ISSN (Online):1999-4915
Copyright Holders:Copyright © 2017 The Author
First Published:First published in Viruses 9(9):245
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
509331Quasispecies evolution in the progression of FIV infectionMargaret HosieWellcome Trust (WELLCOTR)088486/Z/09ZMVLS III - CENTRE FOR VIRUS RESEARCH