One-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

Sloan, N. L., Luthra, S. K., McRobbie, G., Pimlott, S. L. and Sutherland, A. (2017) One-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents. Chemical Communications, 53(80), pp. 11008-11011. (doi: 10.1039/C7CC06211G) (PMID:28849815)

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Abstract

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of 125I-labelled aryl compounds and SPECT radiotracers.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sloan, Miss Nikki and Sutherland, Professor Andrew
Authors: Sloan, N. L., Luthra, S. K., McRobbie, G., Pimlott, S. L., and Sutherland, A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:24 August 2017
Copyright Holders:Copyright © 2017 The Royal Society of Chemistry
First Published:First published in Chemical Communications 53(80): 11008-11011
Publisher Policy:Reproduced under a Creative Commons License

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