Sloan, N. L., Luthra, S. K., McRobbie, G., Pimlott, S. L. and Sutherland, A. (2017) One-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents. Chemical Communications, 53(80), pp. 11008-11011. (doi: 10.1039/C7CC06211G) (PMID:28849815)
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Abstract
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of 125I-labelled aryl compounds and SPECT radiotracers.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sloan, Dr Nikki and Sutherland, Professor Andrew |
| Authors: | Sloan, N. L., Luthra, S. K., McRobbie, G., Pimlott, S. L., and Sutherland, A. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| ISSN (Online): | 1364-548X |
| Published Online: | 24 August 2017 |
| Copyright Holders: | Copyright © 2017 The Royal Society of Chemistry |
| First Published: | First published in Chemical Communications 53(80): 11008-11011 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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