Human toxocariasis

Ma, G., Holland, C. V., Wang, T., Hofmann, A., Fan, C.-K., Maizels, R. M. , Hotez, P. J. and Gasser, R. B. (2018) Human toxocariasis. Lancet Infectious Diseases, 18(1), e14-e24. (doi:10.1016/S1473-3099(17)30331-6) (PMID:28781085)

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Abstract

Parasitic nematodes of the genus Toxocara are socioeconomically important zoonotic pathogens. These parasites are usually directly transmitted to the human host via the faecal-oral route and can cause toxocariasis and associated complications, including allergic and neurological disorders. Although tens of millions of people are estimated to be exposed to or infected with Toxocara spp, global epidemiological information on the relationship between seropositivity and toxocariasis is limited. Recent findings suggest that the effect of toxocariasis on human health is increasing in some countries. Here we review the salient background on Toxocara and biology, summarise key aspects of the pathogenesis, diagnosis, and treatment of toxocariasis, describe what is known about its geographic distribution and prevalence, and make some recommendations for future research towards the prevention and control of this important disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maizels, Professor Rick
Authors: Ma, G., Holland, C. V., Wang, T., Hofmann, A., Fan, C.-K., Maizels, R. M., Hotez, P. J., and Gasser, R. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Lancet Infectious Diseases
Publisher:Elsevier
ISSN:1473-3099
ISSN (Online):1474-4457
Published Online:03 August 2017

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
765221Helminths and the Immune System: Regulation, Regulators and ImmunityRichard MaizelsWellcome Trust (WELLCOTR)106122/A/14/ZIII - PARASITOLOGY
371799The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/Z & AIII - PARASITOLOGY