Metabolic profiling of gestational diabetes in obese women during pregnancy

White, S. L., Pasupathy, D., Sattar, N. , Nelson, S. M. , Lawlor, D. A., Briley, A. L., Seed, P. T., Welsh, P. and Poston, L. (2017) Metabolic profiling of gestational diabetes in obese women during pregnancy. Diabetologia, 60(10), pp. 1903-1912. (doi: 10.1007/s00125-017-4380-6) (PMID:28766127)

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Antenatal obesity and associated gestational diabetes (GDM) are increasing worldwide. While pre-existing insulin resistance is implicated in GDM in obese women, the responsible metabolic pathways remain poorly described. Our aim was to compare metabolic profiles in blood of obese pregnant women with and without GDM 10 weeks prior to and at the time of diagnosis by OGTT. We investigated 646 women, of whom 198 developed GDM, in this prospective cohort study, a secondary analysis of UK Pregnancies Better Eating and Activity Trial (UPBEAT), a multicentre randomised controlled trial of a complex lifestyle intervention in obese pregnant women. Multivariate regression analyses adjusted for multiple testing, and accounting for appropriate confounders including study intervention, were performed to compare obese women with GDM with obese non-GDM women. We measured 163 analytes in serum, plasma or whole blood, including 147 from a targeted NMR metabolome, at time point 1 (mean gestational age 17 weeks 0 days) and time point 2 (mean gestational age 27 weeks 5 days, at time of OGTT) and compared them between groups. Multiple significant differences were observed in women who developed GDM compared with women without GDM (false discovery rate corrected p values <0.05). Most were evident prior to diagnosis. Women with GDM demonstrated raised lipids and lipoprotein constituents in VLDL subclasses, greater triacylglycerol enrichment across lipoprotein particles, higher branched-chain and aromatic amino acids and different fatty acid, ketone body, adipokine, liver and inflammatory marker profiles compared with those without GDM. Among obese pregnant women, differences in metabolic profile, including exaggerated dyslipidaemia, are evident at least 10 weeks prior to a diagnosis of GDM in the late second trimester.

Item Type:Articles
Keywords:Biomarkers, gestational diabetes, lipids, obesity, pregnancy, targeted metabolome.
Glasgow Author(s) Enlighten ID:Nelson, Professor Scott and Welsh, Dr Paul and Sattar, Professor Naveed
Authors: White, S. L., Pasupathy, D., Sattar, N., Nelson, S. M., Lawlor, D. A., Briley, A. L., Seed, P. T., Welsh, P., and Poston, L.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Diabetologia
ISSN (Online):1432-0428
Published Online:01 August 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Diabetologia 60(10): 1903-1912
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
509251Improving pregnancy outcome in obese women (UK Better Eating and Activity Trial - UPBEAT)Naveed SattarNational Institute for Health Research (NIHR)RP-PG-0407-10452RI CARDIOVASCULAR & MEDICAL SCIENCES
629851The UPBEAT RCT mother-child study. Stratifying and treating obese pregnant women to prevent adverse pregnancy, perinatal and longer term outcomesPaul WelshMedical Research Council (MRC)MR/L002477/1RI CARDIOVASCULAR & MEDICAL SCIENCES