Histological features of the distal third metacarpal bone in thoroughbred racehorses, with and without lateral condylar fractures

Pinilla, M.J., Tranquille, C.A., Blunden, A.S., Chang, Y.M., Parkin, T.D.H. and Murray, R.C. (2017) Histological features of the distal third metacarpal bone in thoroughbred racehorses, with and without lateral condylar fractures. Journal of Comparative Pathology, 157(1), pp. 1-10. (doi:10.1016/j.jcpa.2017.04.002) (PMID:28735663)

[img]
Preview
Text
145300.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

1MB

Abstract

A detailed histopathological study of the distal third metacarpal bone of Thoroughbred racehorses was undertaken to characterize lesions observed previously on magnetic resonance imaging (MRI). The bones were selected and grouped on the basis of MRI features. Representative sections in different planes were processed for histopathology. All lesions observed in the articular cartilage (AC) and subchondral bone (SCB) were recorded and graded with a scoring system, based partially on the Osteoarthritis Research Society International grading system. The scoring system included the severity of the lesion. Descriptive statistics and linear mixed effects models were performed. A positive correlation was observed between the severity of histopathological changes in the superficial and deeper osteochondral tissues, and between the number of race starts and AC score. Age was not correlated with AC or SCB score. A moderate variation in AC and SCB scores was observed between the groups; however, there were differences within individual bones. Bones with focal palmar necrosis (FPN) showed significant differences in the histological scoring of the AC compared with bones without FPN. Bones with incomplete fractures or larger areas of bone remodelling showed significant differences in SCB pathology when compared with bones with FPN. Haematoidin was detected in areas with excessive SCB and cancellous bone sclerosis and/or irregular bone density. This finding is suggestive of poor blood perfusion in these areas.

Item Type:Articles
Keywords:Distal third metacarpal bone, histology, horse, lateral condylar fracture.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Parkin, Professor Timothy
Authors: Pinilla, M.J., Tranquille, C.A., Blunden, A.S., Chang, Y.M., Parkin, T.D.H., and Murray, R.C.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of Comparative Pathology
Publisher:Elsevier
ISSN:0021-9975
ISSN (Online):1532-3129
Published Online:20 July 2017
Copyright Holders:Copyright © 2017 Elsevier Ltd.
First Published:First published in Journal of Comparative Pathology 157(1): 1-10
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record