Biosimilar infliximab use in paediatric IBD

Richmond, L., Curtis, L., Garrick, V., Rogers, P., Wilson, M., Tayler, R., Henderson, P., Hansen, R., Wilson, D. C. and Russell, R. K. (2018) Biosimilar infliximab use in paediatric IBD. Archives of Disease in Childhood, 103(1), pp. 89-91. (doi: 10.1136/archdischild-2017-313404) (PMID:28988215)

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Background Biosimilar infliximab became available in the UK in 2015. Paediatric experience to date on its use is limited. We prospectively evaluated the safety and efficacy of biosimilar infliximab (Remsima) in two paediatric gastroenterology networks in patients with inflammatory bowel disease. Methods Prospective clinical data were collected from laboratory reports, electronic patient records and case notes of 40 patients starting Remsima for the first time. Disease activity scores together with blood and stool biomarkers were used to assess response. Results Our data set highlights that Remsima was associated with a significant clinical and biochemical improvement (p<0.01 or less for all parameters assessed) in Crohn’s disease post induction. There were no significant safety issues noted. The total cost saving was £47 800, representing a 38% reduction from originator. Conclusion We found that biosimilar infliximab is as effective as originator infliximab and its use is associated with significant cost savings.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Russell, Dr Richard and Hansen, Dr Richard
Authors: Richmond, L., Curtis, L., Garrick, V., Rogers, P., Wilson, M., Tayler, R., Henderson, P., Hansen, R., Wilson, D. C., and Russell, R. K.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Archives of Disease in Childhood
Publisher:BMJ Publishing Group
ISSN (Online):1468-2044
Published Online:07 October 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Archives of Disease in Childhood 103(1):89-91
Publisher Policy:Reproduced under a Creative Commons License

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