Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space

Cardenas-Rodriguez, M. and Tokatlidis, K. (2017) Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space. FEBS Letters, 591(17), pp. 2661-2670. (doi: 10.1002/1873-3468.12766) (PMID:28746987) (PMCID:PMC5601281)

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Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways. The major thiol-reducing pathways engage the thioredoxin and the glutaredoxin systems which are involved in removal of oxidants, protein proofreading and folding. Alterations in redox balance likely affect the flux of these redox pathways and are related to ageing and diseases such as neurodegenerative disorders and cancer. Here, we first review the well-studied oxidative and reductive processes in the bacterial periplasm and the endoplasmic reticulum, and then discuss the less understood process in the mitochondrial intermembrane space, highlighting its importance for the proper function of the cell.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cardenas Rodriguez, Mr Mauricio and Tokatlidis, Professor Kostas
Authors: Cardenas-Rodriguez, M., and Tokatlidis, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:FEBS Letters
ISSN (Online):1873-3468
Published Online:26 July 2017
First Published:First published in FEBS Letters 591(17):2661–2670

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
497241Scottish Universities Life Sciences Alliance (SULSA)- Cell BiologyGodfrey SmithScottish Funding Council (SFC)HR07019RI CARDIOVASCULAR & MEDICAL SCIENCES
624931Oxidative Folding and Redox Signalling in the Mitochondria Intermembrane Space.Konstantinos TokatlidisThe Royal Society (ROYSOC)WM120111RI MOLECULAR CELL & SYSTEMS BIOLOGY
743461Characterizing the mitochondrial import and assembly pathway of the malaria parasitesKonstantinos TokatlidisWellcome Trust (WELLCOTR)202308/Z/16/ZRI MOLECULAR CELL & SYSTEMS BIOLOGY