Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Sherry, L., Kean, R., McKloud, E., O'Donnell, L. E., Metcalfe, R., Jones, B. L. and Ramage, G. (2017) Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole. Antimicrobial Agents and Chemotherapy, 61(9), e01065-17. (doi:10.1128/AAC.01065-17) (PMID:28696240)

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Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kean, Mr Ryan and Ramage, Professor Gordon and Jones, Dr Brian and Metcalfe, Rebecca and Sherry, Dr Leighann and O'Donnell, Lindsay
Authors: Sherry, L., Kean, R., McKloud, E., O'Donnell, L. E., Metcalfe, R., Jones, B. L., and Ramage, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Antimicrobial Agents and Chemotherapy
Publisher:American Society for Microbiology
ISSN:0066-4804
ISSN (Online):1098-6596
Published Online:10 July 2017
Copyright Holders:Copyright © 2017 American Society for Microbiology
First Published:First published in Antimicrobial Agents and Chemotherapy 61(9): e01065-17
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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