Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Sherry, L. , Kean, R., McKloud, E., O'Donnell, L. E., Metcalfe, R., Jones, B. L. and Ramage, G. (2017) Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole. Antimicrobial Agents and Chemotherapy, 61(9), e01065-17. (doi: 10.1128/AAC.01065-17) (PMID:28696240)

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Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kean, Mr Ryan and Jones, Dr Brian and Sherry, Dr Leighann and Ramage, Professor Gordon and Metcalfe, Rebecca and O'Donnell, Dr Lindsay
Authors: Sherry, L., Kean, R., McKloud, E., O'Donnell, L. E., Metcalfe, R., Jones, B. L., and Ramage, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Antimicrobial Agents and Chemotherapy
Publisher:American Society for Microbiology
ISSN:0066-4804
ISSN (Online):1098-6596
Published Online:10 July 2017
Copyright Holders:Copyright © 2017 American Society for Microbiology
First Published:First published in Antimicrobial Agents and Chemotherapy 61(9): e01065-17
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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