Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Shen, X., Reus, L. M., Cox, S. R., Adams, M. J., Liewald, D. C., Bastin, M. E., Smith, D. J. , Deary, I. J., Whalley, H. C. and McIntosh, A. M. (2017) Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data. Scientific Reports, 7, 5547. (doi:10.1038/s41598-017-05507-6) (PMID:28717197) (PMCID:PMC5514104)

[img]
Preview
Text
144472.pdf - Published Version
Available under License Creative Commons Attribution.

1MB

Abstract

Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n = 1157) and white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy (FA) (β = −0.182, p = 0.005). We also found reductions in FA in association/commissural fibres (β = −0.184, pcorrected = 0.010) and thalamic radiations (β = −0.159, pcorrected = 0.020). Tract-specific FA reductions were also found in the left superior longitudinal fasciculus (β = −0.194, pcorrected = 0.025), superior thalamic radiation (β = −0.224, pcorrected = 0.009) and forceps major (β = −0.193, pcorrected = 0.025) in depression (all betas standardised). Our findings provide further evidence for disrupted white matter integrity in MDD.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smith, Professor Daniel
Authors: Shen, X., Reus, L. M., Cox, S. R., Adams, M. J., Liewald, D. C., Bastin, M. E., Smith, D. J., Deary, I. J., Whalley, H. C., and McIntosh, A. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Published Online:17 July 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Scientific Reports 7:5547
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record