Roger, I., Wilson, C. , Senn, H. M. , Sproules, S. and Symes, M. D. (2017) An investigation into the unusual linkage isomerization and nitrite reduction activity of a novel tris(2-pyridyl) copper complex. Royal Society Open Science, 4(8), 170593. (doi: 10.1098/rsos.170593)
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Abstract
The copper-containing nitrite reductases (CuNIRs) are a class of enzymes that mediate the reduction of nitrite to nitric oxide in biological systems. Metal–ligand complexes that reproduce the salient features of the active site of CuNIRs are therefore of fundamental interest, both for elucidating the possible mode of action of the enzymes and for developing biomimetic catalysts for nitrite reduction. Herein, we describe the synthesis and characterization of a new tris(2-pyridyl) copper complex ([Cu1(NO2)2]) that binds two molecules of nitrite, and displays all three of the common binding modes for NO2−, with one nitrite bound in an asymmetric quasi-bidentate κ2-ONO manner and the other bound in a monodentate fashion with a linkage isomerism between the κ1-ONO and κ1-NO2 binding modes. We use density functional theory to help rationalize the presence of all three of these linkage isomers in one compound, before assessing the redox activity of [Cu1(NO2)2]. These latter studies show that the complex is not a competent nitrite reduction electrocatalyst in non-aqueous solvent, even in the presence of additional proton donors, a finding which may have implications for the design of biomimetic catalysts for nitrite reduction.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Sproules, Dr Stephen and Roger Barba, Isolda and Wilson, Dr Claire and Senn, Dr Hans and Symes, Professor Mark |
Authors: | Roger, I., Wilson, C., Senn, H. M., Sproules, S., and Symes, M. D. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Royal Society Open Science |
Publisher: | The Royal Society |
ISSN: | 2054-5703 |
ISSN (Online): | 2054-5703 |
Published Online: | 16 August 2017 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Royal Society Open Science 4(8): 170593 |
Publisher Policy: | Reproduced under a Creative Commons license |
Data DOI: | 10.5525/gla.researchdata.416 |
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