Spectroscopic oximetry in the eye: a review

MacKenzie, L. E., Harvey, A. R. and McNaught, A. I. (2017) Spectroscopic oximetry in the eye: a review. Expert Review of Ophthalmology, 12(4), pp. 345-356. (doi:10.1080/17469899.2017.1318067)

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Abstract

Introduction: Non-invasive measurement of blood oxygen saturation via spectroscopic imaging has provided insights into ocular physiology and the development of a variety of ocular conditions, including retinal vascular occlusion, diabetic retinopathy and glaucoma. Major developments since the late 90s have been enabled by advancements in imaging technology, computational image analysis, and innovative experimental methods. Areas covered: We review the theory of spectroscopic oximetry, the ocular blood vessels targeted for oximetry, the imaging systems utilised, and methods to validate oximetry measures. We detail the main physiological and clinical insights provided by ocular oximetry. Expert commentary: Oximetry has revealed physiological norms and auto-regulatory effects in the retina, choroid, episcleral, and bulbar conjunctival blood vessels. Retinal oximetry has provided insights into the development of diabetic retinopathy and glaucoma, and may enhance the evaluation and treatment of retinal vessel occlusion. Commercially available retinal oximetry systems have enabled oximetry in the clinical setting. The development of more sophisticated phantoms that resemble in vivo environments has helped validate oximetry applications. New insights into ocular physiology and disease are likely to be gleaned from future studies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Harvey, Professor Andy
Authors: MacKenzie, L. E., Harvey, A. R., and McNaught, A. I.
College/School:College of Science and Engineering > School of Physics and Astronomy
Journal Name:Expert Review of Ophthalmology
Publisher:Taylor & Francis
ISSN:1746-9899
ISSN (Online):1746-9902
Published Online:19 April 2017
Copyright Holders:Copyright © 2017 Taylor and Franics
First Published:First published in Expert Review of Ophthalmology 12(4): 345-356
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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