Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system

Gray, S. R. et al. (2018) Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system. Applied Physiology, Nutrition and Metabolism, 43(1), pp. 84-93. (doi: 10.1139/apnm-2017-0224) (PMID:28903011)

Abstract

Sprint intensity interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT body mass and fat percentage were measured and oral glucose tolerance tests (OGTT) performed in 20 young healthy participants (7 females). Blood gene expression profiles (all 7 mammalian sirtuin genes and 15 enzymes involved in conversion of tryptophan, bioavailable vitamin B3 and metabolic precursors to NAD). NAD/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD/NADP and regulation of components of the sirtuin/NAD system (NAMPT, NMNAT1, CD38 and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin/NAD system to SIT.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gray, Professor Stuart and Wilson, Mr John
• Authors: Gray, S. R., Aird, T. P., Farquharson, A. J., Horgan, G. W., Fisher, E., Wilson, J., Hopkins, G. E., Anderson, B., Ahmad, S. A., Davis, S. R., and Drew, J. E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Applied Physiology, Nutrition and Metabolism
• Publisher: NRC Research Press
• ISSN: 1715-5312
• ISSN (Online): 1715-5320
• Published Online: 13 September 2017
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in Applied Physiology, Nutrition and Metabolism 43(1):84-93
• Publisher Policy: Reproduced in accordance with the publisher copyright policy