An MIF promoter polymorphism is associated with susceptibility to pulmonary arterial hypertension in diffuse cutaneous systemic sclerosis

Bossini-Castillo, L. et al. (2017) An MIF promoter polymorphism is associated with susceptibility to pulmonary arterial hypertension in diffuse cutaneous systemic sclerosis. Journal of Rheumatology, 44(10), pp. 1453-1457. (doi: 10.3899/jrheum.161369) (PMID:28668810)

144172.pdf - Accepted Version



Objective: Systemic sclerosis (SSc) is a fibrotic immune-mediated disease of unknown etiology. Among its clinical manifestations, pulmonary involvement is the leading cause of mortality in patients with SSc. However, the genetic factors involved in lung complication are not well defined. We aimed to review the association of the MIF gene, which encodes a cytokine implicated in idiopathic pulmonary hypertension among other diseases, with the susceptibility and clinical expression of SSc, in addition to testing the association of this polymorphism with SSc-related pulmonary involvement. Methods: A total of 4392 patients with SSc and 16,591 unaffected controls from 6 cohorts of European origin were genotyped for the MIF promoter variant rs755622. An inverse variance method was used to metaanalyze the data. Results: A statistically significant increase of the MIF rs755622*C allele frequency compared with controls was observed in the subgroups of patients with diffuse cutaneous SSc (dcSSc) and with pulmonary arterial hypertension (PAH) independently (dcSSc: p = 3.20E–2, OR 1.13; PAH: p = 2.19E– 02, OR 1.32). However, our data revealed a stronger effect size with the subset of patients with SSc showing both clinical manifestations (dcSSc with PAH: p = 6.91E–3, OR 2.05). Conclusion: We reviewed the association of the MIF rs755622*C allele with SSc and described a phenotype-specific association of this variant with the susceptibility to develop PAH in patients with dcSSc.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Bossini-Castillo, L., Campillo-Davó, D., López-Isac, E., Carmona, F., Simeon, C., Carreira, P., Callejas-Rubio, J. L., Castellví, I., Fernández-Nebro, A., Rodríguez-Rodríguez, L., Rubio-Rivas, M., García-Hernández, F. J., Madroñero, A. B., Beretta, L., Santaniello, A., Lunardi, C., Airó, P., Hoffmann-Vold, A.-M., Kreuter, A., Riemekasten, G., Witte, T., Hunzelmann, N., Vonk, M. C., Voskuyl, A. E., de Vries-Bouwstra, J., Shiels, P., Herrick, A., Worthington, J., Radstake, T. R.D.J., and Martin, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
Journal Name:Journal of Rheumatology
Publisher:Journal of Rheumatology
ISSN (Online):1499-2752
Published Online:01 July 2017
Copyright Holders:Copyright © 2017 Journal of Rheumatology
First Published:First published in Journal of Rheumatology 44(10):1453-1457
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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