Current epigenetic aspects the clinical kidney researcher should embrace

Witasp, A., Van Craenenbroeck, A. H., Shiels, P. G. , Ekström, T. J., Stenvinkel, P. and Nordfors, L. (2017) Current epigenetic aspects the clinical kidney researcher should embrace. Clinical Science, 131(14), pp. 1649-1667. (doi: 10.1042/CS20160596) (PMID:28667065)

144113.pdf - Accepted Version



Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death. Although a wide spectrum of causative factors has been identified and/or suggested, there is still a large gap of knowledge regarding the underlying mechanisms and the complexity of the CKD phenotype. Epigenetic factors, which calibrate the genetic code, are emerging as important players in the CKD-associated pathophysiology. In this article, we review some of the current knowledge on epigenetic modifications and aspects on their role in the perturbed uraemic milieu, as well as the prospect of applying epigenotype-based diagnostics and preventive and therapeutic tools of clinical relevance to CKD patients. The practical realization of such a paradigm will require that researchers apply a holistic approach, including the full spectrum of the epigenetic landscape as well as the variability between and within tissues in the uraemic milieu.

Item Type:Articles
Additional Information:This work was supported by The Swedish Medical Research Council; Heart-Lung Foundation; Loo and Hans Osterman Foundation for Medical Research; Njurfonden; AFA Insurance; Karolinska Institutet Research Funds; and the ERA-EDTA Short Term Fellowship.
Keywords:DNA methylation, chronic kidney disease, epigenetics, microRNA.
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Witasp, A., Van Craenenbroeck, A. H., Shiels, P. G., Ekström, T. J., Stenvinkel, P., and Nordfors, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Clinical Science
Publisher:Portland Press
ISSN (Online):1470-8736
Published Online:30 June 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Clinical Science 131(14): 1649-1667
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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