Bioavailability of black tea theaflavins: absorption, metabolism, and colonic catabolism

Pereira-Caro, G., Moreno-Rojas, J. M., Brindani, N., Del Rio, D., Lean, M. E.J. , Hara, Y. and Crozier, A. (2017) Bioavailability of black tea theaflavins: absorption, metabolism, and colonic catabolism. Journal of Agricultural and Food Chemistry, 65(26), pp. 5365-5374. (doi:10.1021/acs.jafc.7b01707) (PMID:28595385)

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Abstract

Data obtained with in vitro fecal incubations and a feeding study indicate black tea theaflavin and its galloyl derivatives are not absorbed in detectable amounts in either the upper or lower gastrointestinal tract. The theaflavin skeleton is comparatively resistant to degradation by colonic bacteria with a 67% recovery being obtained after a 24 h incubation, which yielded 21 phenolic and aromatic catabolites. The theaflavin galloyl moiety was removed by the microbiota, and the released gallic acid further transformed to 3-O- and 4-O-methyl gallic acids, pyrogallol-1-sulfate and pyrogallol-2-sulfate, which were excreted in urine in amounts equivalent to 94% of intake. The main urinary product potentially derived from breakdown of the theaflavin skeleton was 3-(4′-hydroxyphenyl)propionic acid. A number of the colonic catabolites originating from gallic acid and theaflavins has been reported to be bioactive in ex vivo and in vitro models with a variety of potential modes of action.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lean, Professor Michael
Authors: Pereira-Caro, G., Moreno-Rojas, J. M., Brindani, N., Del Rio, D., Lean, M. E.J., Hara, Y., and Crozier, A.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Agricultural and Food Chemistry
Publisher:American Chemical Society (ACS)
ISSN:0021-8561
ISSN (Online):1520-5118
Published Online:09 June 2017
Copyright Holders:Copyright © 2017 American Chemical Society
First Published:Journal of Agricultural and Food Chemistry 65(26):5365-5374
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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