Molecular definitions of autophagy and related processes

Galluzzi, L. et al. (2017) Molecular definitions of autophagy and related processes. EMBO Journal, 36(13), pp. 1811-1836. (doi:10.15252/embj.201796697) (PMID:28596378)

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Abstract

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy‐related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy‐related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin
Authors: Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., Cuervo, A. M., Debnath, J., Deretic, V., Dikic, I., Eskelinen, E.‐L., Fimia, G. M., Fulda, S., Gewirtz, D. A., Green, D. R., Hansen, M., Harper, J. W., Jäättelä, M., Johansen, T., Juhasz, G., Kimmelman, A. C., Kraft, C., Ktistakis, N. T., Kumar, S., Levine, B., Lopez‐Otin, C., Madeo, F., Martens, S., Martinez, J., Melendez, A., Mizushima, N., Münz, C., Murphy, L. O., Penninger, J. M., Piacentini, M., Reggiori, F., Rubinsztein, D. C., Ryan, K. M., Santambrogio, L., Scorrano, L., Simon, A. K., Simon, H.‐U., Simonsen, A., Tavernarakis, N., Tooze, S. A., Yoshimori, T., Yuan, J., Yue, Z., Zhong, Q., and Kroemer, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:EMBO Journal
Publisher:EMBO Press
ISSN:0261-4189
ISSN (Online):1460-2075
Published Online:08 June 2017

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