Role of the cerebellum in adaptation to delayed action effects

Cao, L., Veniero, D., Thut, G. and Gross, J. (2017) Role of the cerebellum in adaptation to delayed action effects. Current Biology, 27(16), 2442-2451.e3. (doi: 10.1016/j.cub.2017.06.074) (PMID:28781049) (PMCID:PMC5571438)

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Abstract

Actions are typically associated with sensory consequences. For example, knocking at a door results in predictable sounds. These self-initiated sensory stimuli are known to elicit smaller cortical responses compared to passively presented stimuli, e.g., early auditory evoked magnetic fields known as M100 and M200 components are attenuated. Current models implicate the cerebellum in the prediction of the sensory consequences of our actions. However, causal evidence is largely missing. In this study, we introduced a constant delay (of 100 ms) between actions and action-associated sounds, and we recorded magnetoencephalography (MEG) data as participants adapted to the delay. We found an increase in the attenuation of the M100 component over time for self-generated sounds, which indicates cortical adaptation to the introduced delay. In contrast, no change in M200 attenuation was found. Interestingly, disrupting cerebellar activity via transcranial magnetic stimulation (TMS) abolished the adaptation of M100 attenuation, while the M200 attenuation reverses to an M200 enhancement. Our results provide causal evidence for the involvement of the cerebellum in adapting to delayed action effects, and thus in the prediction of the sensory consequences of our actions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cao, Dr Liyu and Thut, Professor Gregor and Gross, Professor Joachim and Veniero, Dr Domenica
Authors: Cao, L., Veniero, D., Thut, G., and Gross, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Current Biology
Publisher:Elsevier
ISSN:0960-9822
ISSN (Online):1879-0445
Published Online:03 August 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Current Biology 27(16): 2442-2452.e3
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
597051Natural and modulated neural communication: State-dependent decoding and driving of human Brain Oscillations.Joachim GrossWellcome Trust (WELLCOTR)098433/Z/12/ZINP - CENTRE FOR COGNITIVE NEUROIMAGING
597911Natural and modulated neural communication: State-dependent decoding and driving of human Brain OscillationsGregor ThutWellcome Trust (WELLCOTR)098434/Z/12/ZINP - CENTRE FOR COGNITIVE NEUROIMAGING