The role of epigenetics in renal ageing

Shiels, P. G. , McGuinness, D., Eriksson, M., Kooman, J. P. and Stenvinkel, P. (2017) The role of epigenetics in renal ageing. Nature Reviews Nephrology, 13, pp. 471-482. (doi: 10.1038/nrneph.2017.78) (PMID:28626222)

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An ability to separate natural ageing processes from processes specific to morbidities is required to understand the heterogeneity of age-related organ dysfunction. Mechanistic insight into how epigenetic factors regulate ageing throughout the life course, linked to a decline in renal function with ageing, is already proving to be of value in the analyses of clinical and epidemiological cohorts. Noncoding RNAs provide epigenetic regulatory circuits within the kidney, which reciprocally interact with DNA methylation processes, histone modification and chromatin. These interactions have been demonstrated to reflect the biological age and function of renal allografts. Epigenetic factors control gene expression and activity in response to environmental perturbations. They also have roles in highly conserved signalling pathways that modulate ageing, including the mTOR and insulin/insulin-like growth factor signalling pathways, and regulation of sirtuin activity. Nutrition, the gut microbiota, inflammation and environmental factors, including psychosocial and lifestyle stresses, provide potential mechanistic links between the epigenetic landscape of ageing and renal dysfunction. Approaches to modify the renal epigenome via nutritional intervention, targeting the methylome or targeting chromatin seem eminently feasible, although caution is merited owing to the potential for intergenerational and transgenerational effects.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McGuinness, Dr Dagmara and Shiels, Professor Paul
Authors: Shiels, P. G., McGuinness, D., Eriksson, M., Kooman, J. P., and Stenvinkel, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Nature Reviews Nephrology
Publisher:Nature Publishing Group
ISSN (Online):1759-507X
Published Online:19 June 2017
Copyright Holders:Copyright © 2017 Macmillan Publishers Limited, part of Springer Nature
First Published:First published in Nature Reviews Nephrology 13:471-482
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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