Shiels, P. G. , McGuinness, D., Eriksson, M., Kooman, J. P. and Stenvinkel, P. (2017) The role of epigenetics in renal ageing. Nature Reviews Nephrology, 13, pp. 471-482. (doi: 10.1038/nrneph.2017.78) (PMID:28626222)
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Abstract
An ability to separate natural ageing processes from processes specific to morbidities is required to understand the heterogeneity of age-related organ dysfunction. Mechanistic insight into how epigenetic factors regulate ageing throughout the life course, linked to a decline in renal function with ageing, is already proving to be of value in the analyses of clinical and epidemiological cohorts. Noncoding RNAs provide epigenetic regulatory circuits within the kidney, which reciprocally interact with DNA methylation processes, histone modification and chromatin. These interactions have been demonstrated to reflect the biological age and function of renal allografts. Epigenetic factors control gene expression and activity in response to environmental perturbations. They also have roles in highly conserved signalling pathways that modulate ageing, including the mTOR and insulin/insulin-like growth factor signalling pathways, and regulation of sirtuin activity. Nutrition, the gut microbiota, inflammation and environmental factors, including psychosocial and lifestyle stresses, provide potential mechanistic links between the epigenetic landscape of ageing and renal dysfunction. Approaches to modify the renal epigenome via nutritional intervention, targeting the methylome or targeting chromatin seem eminently feasible, although caution is merited owing to the potential for intergenerational and transgenerational effects.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McGuinness, Dr Dagmara and Shiels, Professor Paul |
| Authors: | Shiels, P. G., McGuinness, D., Eriksson, M., Kooman, J. P., and Stenvinkel, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Nephrology |
| Publisher: | Nature Publishing Group |
| ISSN: | 1759-5061 |
| ISSN (Online): | 1759-507X |
| Published Online: | 19 June 2017 |
| Copyright Holders: | Copyright © 2017 Macmillan Publishers Limited, part of Springer Nature |
| First Published: | First published in Nature Reviews Nephrology 13:471-482 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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