Managing rheumatic and musculoskeletal diseases - past, present and future

Burmester, G. R., Bijlsma, J. W.J., Cutolo, M. and McInnes, I. B. (2017) Managing rheumatic and musculoskeletal diseases - past, present and future. Nature Reviews Rheumatology, 13(7), pp. 443-448. (doi:10.1038/nrrheum.2017.95) (PMID:28615732)

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Abstract

Progress in rheumatology has been remarkable in the past 70 years, favourably affecting quality of life for people with rheumatic and musculoskeletal diseases. Therapeutics have advanced considerably in this period, from early developments such as the introduction of glucocorticoid therapy to the general use of methotrexate and other disease-modifying agents, followed by the advent of biologic DMARDs and, most recently, small-molecule signalling inhibitors. Novel strategies for the use of such agents have also transformed outcomes, as have multidisciplinary nonpharmacological approaches to the management of rheumatic musculoskeletal disease including surgery, physical therapy and occupational therapy. Breakthroughs in our understanding of disease pathogenesis, diagnostics and the use of 'big data' continue to drive the field forward. Critically, the patient is now at the centre of management strategies as well as the future research agenda.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain
Authors: Burmester, G. R., Bijlsma, J. W.J., Cutolo, M., and McInnes, I. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Reviews Rheumatology
Publisher:Nature Publishing Group
ISSN:1759-4790
ISSN (Online):1759-4804
Published Online:15 June 2017
Copyright Holders:Copyright © 2017 Nature Publishing Group
First Published:First published in Nature Reviews Rheumatology 13(7):443-448
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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