The role of Ghrelin in neuroprotection after ischemic brain injury

Spencer, S., Miller, A. and Andrews, Z. (2013) The role of Ghrelin in neuroprotection after ischemic brain injury. Brain Sciences, 3(1), pp. 344-359. (doi: 10.3390/brainsci3010344) (PMID:24961317) (PMCID:PMC4061836)

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Abstract

Ghrelin, a gastrointestinal peptide with a major role in regulating feeding and metabolism, has recently been investigated for its neuroprotective effects. In this review we discuss pre-clinical evidence suggesting ghrelin may be a useful therapeutic in protecting the brain against injury after ischemic stroke. Specifically, we will discuss evidence showing ghrelin administration can improve neuronal cell survival in animal models of focal cerebral ischemia, as well as rescue memory deficits. We will also discuss its proposed mechanisms of action, including anti-apoptotic and anti-inflammatory effects, and suggest ghrelin treatment may be a useful intervention after stroke in the clinic.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Miller, Dr Alyson
Authors: Spencer, S., Miller, A., and Andrews, Z.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Brain Sciences
Publisher:MDPI
ISSN:2076-3425
ISSN (Online):2076-3425
Copyright Holders:copyright © 2013 The Authors
First Published:First published in Brain Sciences 3:344-359
Publisher Policy:Reproduced under a creative commons license

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