A coupled mitral valve - left ventricle model with fluid-structure interaction

Gao, H. , Feng, L., Qi, N., Berry, C. , Griffith, B. E. and Luo, X. (2017) A coupled mitral valve - left ventricle model with fluid-structure interaction. Medical Engineering and Physics, 47, pp. 128-136. (doi:10.1016/j.medengphy.2017.06.042) (PMID:28751011)

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Abstract

Understanding the interaction between the valves and walls of the heart is important in assessing and subsequently treating heart dysfunction. This study presents an integrated model of the mitral valve (MV) coupled to the left ventricle (LV), with the geometry derived from in vivo clinical magnetic resonance images. Numerical simulations using this coupled MV–LV model are developed using an immersed boundary/finite element method. The model incorporates detailed valvular features, left ventricular contraction, nonlinear soft tissue mechanics, and fluid-mediated interactions between the MV and LV wall. We use the model to simulate cardiac function from diastole to systole. Numerically predicted LV pump function agrees well with in vivo data of the imaged healthy volunteer, including the peak aortic flow rate, the systolic ejection duration, and the LV ejection fraction. In vivo MV dynamics are qualitatively captured. We further demonstrate that the diastolic filling pressure increases significantly with impaired myocardial active relaxation to maintain a normal cardiac output. This is consistent with clinical observations. The coupled model has the potential to advance our fundamental knowledge of mechanisms underlying MV–LV interaction, and help in risk stratification and optimisation of therapies for heart diseases.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gao, Dr Hao and Feng, Mr Liuyang and Berry, Professor Colin and Qi, Dr Nan and Griffith, Dr Boyce
Authors: Gao, H., Feng, L., Qi, N., Berry, C., Griffith, B. E., and Luo, X.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Science and Engineering > School of Mathematics and Statistics
Journal Name:Medical Engineering and Physics
Publisher:Elsevier
ISSN:1350-4533
ISSN (Online):1873-4030
Published Online:25 July 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Medical Engineering and Physics 47:128-136
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
694461EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancerRaymond OgdenEngineering and Physical Sciences Research Council (EPSRC)EP/N014642/1M&S - MATHEMATICS
560111Finite element-immersed boundary method and its application to mitral valvesXiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/I029990/1M&S - MATHEMATICS
662681"First steps towards modelling myocardial infarction (a computed MI Physiome): A case-control study of novel biomechanical parameters in acute MI survivors with left ventricular dysfunction."Colin BerryBritish Heart Foundation (BHF)PG/14/64/31043RI CARDIOVASCULAR & MEDICAL SCIENCES
689601The first fully coupled mitral valve - left ventricle computational modelXiaoyu LuoLeverhulme Trust (LEVERHUL)RF-2015-510M&S - MATHEMATICS