Serine and functional metabolites in cancer

Newman, A. C. and Maddocks, O. D.K. (2017) Serine and functional metabolites in cancer. Trends in Cell Biology, 27(9), pp. 645-657. (doi:10.1016/j.tcb.2017.05.001) (PMID:28601431)

Newman, A. C. and Maddocks, O. D.K. (2017) Serine and functional metabolites in cancer. Trends in Cell Biology, 27(9), pp. 645-657. (doi:10.1016/j.tcb.2017.05.001) (PMID:28601431)

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Abstract

Folate metabolism functions to supply one-carbon units that are vital for a range of biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units, rendering them dependent upon extracellular serine uptake or de novo serine synthesis for maximal growth and proliferation. One-carbon units are required for the production of critical cellular components, such as nucleotides, which enable cancer cells to maintain high proliferate rates. Of recent interest, one-carbon metabolism contributes to the biosynthesis and recycling of functional metabolites, such as ATP, S-adenosyl-methionine (SAM), and NAD(P)H, with important downstream consequences for cancer cell survival. In this review, we describe recent advances in our understanding of the importance of one-carbon metabolism in cancer, focussing upon the routes through which cancer cells obtain and use one-carbon units.

Item Type:Articles
Keywords:Cancer, functional metabolites, one-carbon metabolism, serine metabolism.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Newman, Dr Alice and Maddocks, Dr Oliver
Authors: Newman, A. C., and Maddocks, O. D.K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Trends in Cell Biology
Publisher:Elsevier
ISSN:0962-8924
ISSN (Online):1879-3088
Published Online:07 June 2017

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
666241Targeting Tumour Metabolism for Cancer Therapy and Diagnosis.Oliver MaddocksCancer Research UK (CRUK)19702RI CANCER SCIENCES