Newman, A. C. and Maddocks, O. D.K. (2017) Serine and functional metabolites in cancer. Trends in Cell Biology, 27(9), pp. 645-657. (doi: 10.1016/j.tcb.2017.05.001) (PMID:28601431)
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Abstract
Folate metabolism functions to supply one-carbon units that are vital for a range of biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units, rendering them dependent upon extracellular serine uptake or de novo serine synthesis for maximal growth and proliferation. One-carbon units are required for the production of critical cellular components, such as nucleotides, which enable cancer cells to maintain high proliferate rates. Of recent interest, one-carbon metabolism contributes to the biosynthesis and recycling of functional metabolites, such as ATP, S-adenosyl-methionine (SAM), and NAD(P)H, with important downstream consequences for cancer cell survival. In this review, we describe recent advances in our understanding of the importance of one-carbon metabolism in cancer, focussing upon the routes through which cancer cells obtain and use one-carbon units.
| Item Type: | Articles |
|---|---|
| Keywords: | Cancer, functional metabolites, one-carbon metabolism, serine metabolism. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Newman, Dr Alice and Maddocks, Professor Oliver |
| Authors: | Newman, A. C., and Maddocks, O. D.K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Trends in Cell Biology |
| Publisher: | Elsevier |
| ISSN: | 0962-8924 |
| ISSN (Online): | 1879-3088 |
| Published Online: | 07 June 2017 |
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