Evans, T. and secher, D. (1984) Kinetics of internalisation and degradation of surface-bound interferon in human lymphoblastoid cells. EMBO Journal, 3(12), pp. 2975-2978. (PMID:6241148) (PMCID:PMC557800)
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Abstract
The binding of iodinated human interferon-alpha 2 (IFN-alpha 2) was studied on the human T cell line, Molt 4. After its initial binding to cells, the IFN is transferred to a trypsin-resistant compartment before appearing in the medium as TCA-soluble material, while the total cell-associated IFN declines to one-third of its maximum value after 3 h incubation. The Na+/H+ ionophore monensin did not prevent intracellular accumulation of IFN but did completely inhibit its breakdown. We interpret our results as evidence for receptor-mediated internalisation of IFN followed by intracellular breakdown.
Item Type: | Articles |
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Refereed: | No |
Glasgow Author(s) Enlighten ID: | Evans, Professor Tom |
Authors: | Evans, T., and secher, D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | EMBO Journal |
Publisher: | EMBO Press |
ISSN: | 0261-4189 |
ISSN (Online): | 1460-2075 |
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