Dadmarz, R., Evans, T. , Secher, D., Marshall, N. and Cawley, J. (1986) The mechanism of action of interferon-α (IFN-α) in hairy-cell leukaemia; Hu-IFN-α2 receptor expression by hairy cells and other normal and leukaemic cell types. Leukemia Research, 10(11), pp. 1279-1285.
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Abstract
To investigate the possible direct effects of interferon-α (IFN-α) in hairy-cell leukaemia, IFN-α receptor expression by hairy cells (HCs) (11 cases) was measured by a radiolabelling technique and compared with that of MOLT-4, chronic lymphocytic leukaemia (CLL; 14 cases) and various other leukaemic and normal cell types. Purified peripheral blood (PB) and splenic HCs showed higher levels of receptor expression (approx. 1000 ± 200 binding sites/cell; 11 cases tested) than other normal and leukaemic cells types. Purified normal PB and tonsil B cells showed low levels of receptors (approx. 120 ± 100 binding sites/cell), while a range of B-cell leukaemias displayed intermediate levels of expression (approx. 100–500 sites/cell). In the 15 cases of CLL tested, 530 ± 330 binding sites/cell were demonstrated, the high standard deviation reflecting the fact that approximately one third of cases had receptor levels comparable with those in HCL. Normal and HCL T cells, red cells and platelets had no demonstrable IFN receptors. It is suggested that these findings may be relevant to the efficacy of IFN in hairy-cell leukaemia.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Evans, Professor Tom |
Authors: | Dadmarz, R., Evans, T., Secher, D., Marshall, N., and Cawley, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Leukemia Research |
Publisher: | Elsevier |
ISSN: | 0145-2126 |
ISSN (Online): | 1873-5835 |
Published Online: | 01 March 2004 |
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