Spectrum of slow and super-slow (picosecond to nanosecond) water dynamics around organic and biological solutes

Ramakrishnan, G., González-Jiménez, M. , Lapthorn, A. J. and Wynne, K. (2017) Spectrum of slow and super-slow (picosecond to nanosecond) water dynamics around organic and biological solutes. Journal of Physical Chemistry Letters, 8(13), pp. 2964-2970. (doi:10.1021/acs.jpclett.7b01127) (PMID:28612605)

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Abstract

Water dynamics in the solvation shell of solutes plays a very important role in the interaction of biomolecules and in chemical reaction dynamics. However, a selective spectroscopic study of the solvation shell is difficult because of the interference of the solute dynamics. Here we report on the observation of heavily slowed down water dynamics in the solvation shell of different solutes by measuring the low-frequency spectrum of solvation water, free from the contribution of the solute. A slowdown factor of ~50 is observed even for relatively low concentrations of the solute. We go on to show that the effect can be generalized to different solutes including proteins.

Item Type:Articles
Additional Information:Also acknowledge award EP/J00975X/1 to University of Strathclyde.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ramakrishnan, Dr Gopakumar and Wynne, Professor Klaas and Lapthorn, Dr Adrian and Gonzalez Jimenez, Dr Mario
Authors: Ramakrishnan, G., González-Jiménez, M., Lapthorn, A. J., and Wynne, K.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Physical Chemistry Letters
Publisher:American Chemical Society
ISSN:1948-7185
ISSN (Online):1948-7185
Published Online:14 June 2017
Copyright Holders:Copyright © 2017 American Chemical Society
First Published:First published in Journal of Physical Chemistry Letters 8(13):2964–2970
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
582891The structure and dynamics of water confined in nanoscale pools: the dynamic crossoverKlaas WynneEngineering and Physical Sciences Research Council (EPSRC)EP/J009733/1CHEM - CHEMISTRY
619561Solvation dynamics and structure around proteins and peptides: collective network motions vs. weak interactionsKlaas WynneEngineering and Physical Sciences Research Council (EPSRC)EP/K034995/1CHEM - CHEMISTRY
709791EPSRC-ISF 2015: A dynamic Perspective on Biomolecular Function and ReactivityKlaas WynneEngineering and Physical Sciences Research Council (EPSRC)EP/N508792/1CHEM - CHEMISTRY