Ferumoxytol-enhanced magnetic resonance angiography for the assessment of potential kidney transplant recipients

Stoumpos, S., Hennessy, M., Vesey, A. T., Radjenovic, A. , Kasthuri, R., Kingsmore, D. B., Mark, P. B. and Roditi, G. (2018) Ferumoxytol-enhanced magnetic resonance angiography for the assessment of potential kidney transplant recipients. European Radiology, 28(1), pp. 115-123. (doi: 10.1007/s00330-017-4934-5) (PMID:28677065) (PMCID:PMC5717122)

Abstract

Objectives: Traditional contrast-enhanced methods for scanning blood vessels using magnetic resonance imaging (MRI) or CT carry potential risks for patients with advanced kidney disease. Ferumoxytol is a superparamagnetic iron oxide nanoparticle preparation that has potential as an MRI contrast agent in assessing the vasculature. Methods: Twenty patients with advanced kidney disease requiring aorto-iliac vascular imaging as part of pre-operative kidney transplant candidacy assessment underwent ferumoxytol-enhanced magnetic resonance angiography (FeMRA) between December 2015 and August 2016. All scans were performed for clinical indications where standard imaging techniques were deemed potentially harmful or inconclusive. Image quality was evaluated for both arterial and venous compartments. Results: First-pass and steady-state FeMRA using incremental doses of up to 4 mg/kg body weight of ferumoxytol as intravenous contrast agent for vascular enhancement was performed. Good arterial and venous enhancements were achieved, and FeMRA was not limited by calcification in assessing the arterial lumen. The scans were diagnostic and all patients completed their studies without adverse events. Conclusions: Our preliminary experience supports the feasibility and utility of FeMRA for vascular imaging in patients with advanced kidney disease due for transplant listing, which has the advantages of obtaining both arteriography and venography using a single test without nephrotoxicity.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Roditi, Dr Giles and Kasthuri, Dr Ram and Mark, Professor Patrick and Stoumpos, Dr Sokratis and Kingsmore, Prof David and Radjenovic, Dr Aleksandra
• Authors: Stoumpos, S., Hennessy, M., Vesey, A. T., Radjenovic, A., Kasthuri, R., Kingsmore, D. B., Mark, P. B., and Roditi, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: European Radiology
• Publisher: Springer
• ISSN: 0938-7994
• ISSN (Online): 1432-1084
• Published Online: 04 July 2017
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in European Radiology 28(1): 115-123
• Publisher Policy: Reproduced under a Creative Commons License