Viral encephalitis of unknown cause: current perspective and recent advances

Kennedy, P. G.E., Quan, P.-L. and Lipkin, W. I. (2017) Viral encephalitis of unknown cause: current perspective and recent advances. Viruses, 9(6), 138. (doi: 10.3390/v9060138)

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Abstract

Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are implicated. Up to 60% of cases of presumed viral encephalitis remain unexplained due to the failure of conventional laboratory techniques to detect an infectious agent. High-throughput DNA sequencing technologies have the potential to detect any microbial nucleic acid present in a biological specimen without any prior knowledge of the target sequence. While there remain challenges intrinsic to these technologies, they have great promise in virus discovery in unexplained encephalitis.

Item Type:Articles
Additional Information:Research described in this article was funded by HHS|National Institutes of Health (NIH) (AI109761).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Authors: Kennedy, P. G.E., Quan, P.-L., and Lipkin, W. I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Viruses
Publisher:MDPI
ISSN:1999-4915
ISSN (Online):1999-4915
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Viruses 9(6): 138
Publisher Policy:Reproduced under a Creative Commons License

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