Advances and challenges in barcoding pathogenic and environmental Leptospira

Guernier, V., Allan, K. J. and Gourant, C. (2018) Advances and challenges in barcoding pathogenic and environmental Leptospira. Parasitology, 145, pp. 595-607. (doi: 10.1017/S0031182017001147) (PMID:28716157) (PMCID:PMC6010154)

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Abstract

Leptospirosis is a zoonotic bacterial disease of global importance. A large spectrum of asymptomatic animal hosts can carry the infection and contribute to the burden of human disease. Environmental sources of human contamination also point to the importance of a hydrotelluric reservoir. Leptospirosis can be caused by as many as 15 different pathogenic or intermediate Leptospira species. However, classification of these bacteria remains complicated through the use of both serological and genetic classification systems that show poor correlation. With the advent of molecular techniques, DNA-based barcoding offers a conceptual framework that can be used for leptospirosis surveillance as well as source tracking. In this review, we summarize some of the current techniques, highlight significant successes and weaknesses and point to the future opportunities and challenges to successfully establish a widely applicable barcoding scheme for Leptospira.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Allan, Dr Kathryn
Authors: Guernier, V., Allan, K. J., and Gourant, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Parasitology
Publisher:Cambridge University Press
ISSN:0031-1820
ISSN (Online):1469-8161
Published Online:18 July 2017
Copyright Holders:Copyright © 2017 Cambridge University Press
First Published:First published in Parasitology 145:595-607
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
573981Leptospirosis in Tanzania; a study of the role of rodents in an emerging public health problem.Sarah CleavelandWellcome Trust (WELLCOTR)096400/Z/11/ZRI BIODIVERSITY ANIMAL HEALTH & COMPMED