Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi: 10.1161/CIRCRESAHA.117.310672) (PMID:28546356) (PMCID:PMC5520661)
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Abstract
Although convincing experimental evidence demonstrates the importance of vascular reactive oxygen and nitrogen species (RONS), oxidative stress, and perturbed redox signaling as causative processes in the vasculopathy of hypertension, this has not translated to the clinic. We discuss this bench-to-bedside disparity and the urgency to progress vascular redox pathobiology from experimental models to patients by studying disease-relevant human tissues. It is only through such approaches that the unambiguous role of vascular redox stress will be defined so that mechanism-based therapies in a personalized and precise manner can be developed to prevent, slow, or reverse progression of small-vessel disorders and consequent hypertension.
Item Type: | Articles |
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Keywords: | Blood pressure, cardiovascular diseases, hypertension, oxidative stress, stroke. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Rios, Dr Francisco and Montezano, Dr Augusto and Touyz, Professor Rhian |
Authors: | Touyz, R. M., Montezano, A. C., Rios, F., Widlansky, M. E., and Liang, M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Circulation Research |
Publisher: | American Heart Association |
ISSN: | 0009-7330 |
ISSN (Online): | 1524-4571 |
Published Online: | 25 May 2017 |
Copyright Holders: | Copyright © 2017 American Heart Association, Inc. |
First Published: | First published in Circulation Research 120(11): 1721-1723 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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