Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap?

Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi:10.1161/CIRCRESAHA.117.310672) (PMID:28546356)

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Abstract

Although convincing experimental evidence demonstrates the importance of vascular reactive oxygen and nitrogen species (RONS), oxidative stress, and perturbed redox signaling as causative processes in the vasculopathy of hypertension, this has not translated to the clinic. We discuss this bench-to-bedside disparity and the urgency to progress vascular redox pathobiology from experimental models to patients by studying disease-relevant human tissues. It is only through such approaches that the unambiguous role of vascular redox stress will be defined so that mechanism-based therapies in a personalized and precise manner can be developed to prevent, slow, or reverse progression of small-vessel disorders and consequent hypertension.

Item Type:Articles
Keywords:Blood pressure, cardiovascular diseases, hypertension, oxidative stress, stroke.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Rios, Dr Francisco and Montezano, Dr Augusto and Touyz, Professor Rhian
Authors: Touyz, R. M., Montezano, A. C., Rios, F., Widlansky, M. E., and Liang, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Circulation Research
Publisher:American Heart Association
ISSN:0009-7330
ISSN (Online):1524-4571
Published Online:25 May 2017
Copyright Holders:Copyright © 2017 American Heart Association, Inc.
First Published:First published in Circulation Research 120(11): 1721-1723
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
607381Vascular Noxs as therapeutic targets and biomarkers in hypertensionRhian TouyzBritish Heart Foundation (BHF)CH/12/4/29762RI CARDIOVASCULAR & MEDICAL SCIENCES
607382Vascular Noxs as therapeutic targets and biomarkers in hypertensionRhian TouyzBritish Heart Foundation (BHF)RG/13/7/30099RI CARDIOVASCULAR & MEDICAL SCIENCES
597321RADOX: RADical reduction of OXidative stress in cardiovascular diseasesRhian TouyzEuropean Commission (EC)PITN-GA-2012-316738RI CARDIOVASCULAR & MEDICAL SCIENCES