Longitudinal study of the influence of lung function on vascular health from adolescence to early adulthood in a British multi-ethnic cohort

Lu, Y., Sooky, L., Silva, M. J., Molaodi, O. R., Karamanos, A., Cruickshank, J. K. and Harding, S. (2017) Longitudinal study of the influence of lung function on vascular health from adolescence to early adulthood in a British multi-ethnic cohort. Journal of Hypertension, 35(11), pp. 2185-2191. (doi:10.1097/HJH.0000000000001455) (PMID:28661960) (PMCID:PMC5625963)

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Abstract

Background: Vascular and lung function develop and decline over the life course; both predict cardiovascular events and mortality but little is known of how they develop over time. We analysed their relationship in a multiethnic cohort study to test whether lung function from early adolescence to young adulthood affected vascular indices. Methods: 'DASH' ( http://dash.sphsu.mrc.ac.uk) included 6643 children aged 11-13 years in 2003; a representative 10% sample (n = 665) participated in a pilot follow-up in 2013. Psychosocial, anthropometric, blood pressure (BP), and lung function measures were collected in both surveys; aortic pulse wave velocity (PWV) and augmentation index (AIx) were measured at aged 21-23 years. Relationships between forced expiratory volume Z-scores in 1 s (zFEV1), after global initiative-ethnic adjustments and BP, PWV, and AIx were tested in linear regression and general estimating statistical models. Results: In total, 488 people with complete data were included. At 11-13 years, SBP was positively associated with zFEV1 (coefficient = 1.90, 95% confidence interval 1.11-2.68, P < 0.001); but not at 21-23 years. The 10-year increase in zFEV1 was associated with rise in SBP (1.38, 0.25-1.51, P < 0.05) in mixed effect models adjusted for age, sex, ethnicity, waist to height ratio, employment, reported racism, smoking, and alcohol use but DBP change was unrelated. In fully adjusted models, neither PWV nor central AIx were associated with zFEV1 at 11-13 years or 21-23 years (P > 0.05). Conclusion: Forced expiratory volume change is positively and independently associated with SBP change from adolescence to young adulthood, suggesting earlier lung function plays important roles in SBP development. Vascular indices were unrelated to lung function or its change.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Molaodi, Dr Oarabile
Authors: Lu, Y., Sooky, L., Silva, M. J., Molaodi, O. R., Karamanos, A., Cruickshank, J. K., and Harding, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO Unit
Journal Name:Journal of Hypertension
Publisher:Lippincott Williams & Wilkins
ISSN:0263-6352
ISSN (Online):1526-632X
Published Online:28 June 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Journal of Hypertension 35(11):2185-2191
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656561Ethnicity and healthSeeromanie HardingMedical Research Council (MRC)MC_UU_12017/1IHW - MRC/CSO SPHU
727651SPHSU Core Renewal: Measuring and Analysing Socioeconomic Inequalities in Health Research ProgrammeAlastair LeylandMedical Research Council (MRC)MC_UU_12017/13IHW - MRC/CSO SPHU