Thioether-catalysed tandem synthesis of furans and cyclic ethers or lactones

Klaus, V. and Clark, J. S. (2017) Thioether-catalysed tandem synthesis of furans and cyclic ethers or lactones. Synlett, 28(11), pp. 1358-1362. (doi:10.1055/s-0036-1588758)

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Abstract

Acyclic conjugated ynenediones tethered to an alcohol or carboxylic acid are converted into furanyl-substituted cyclic ethers or lactones in a single step by treatment with the tetrahydrothiophene. Modest levels of diastereocontrol can be achieved in some cases where the presence of a substituent on the tether results in the creation of a second stereogenic centre upon formation of the cyclic ether or lactone.

Item Type:Articles (Letter)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Klaus, Miss Verena and Clark, Professor Stephen
Authors: Klaus, V., and Clark, J. S.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Synlett
Publisher:Thieme Publishing
ISSN:0936-5214
ISSN (Online):1437-2096
Published Online:20 March 2017
Copyright Holders:Copyright © 2017 Georg Thieme Verlag
First Published:First published in Synlett 28(11):1358-1362
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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