Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes

Jenks, S. J., Conway, B. R., McLachlan, S., Teoh, W. L., Williamson, R. M., Webb, D. J., Welsh, P., Sattar, N. , Strachan, M. W.J. and Price, J. F. (2017) Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes. Diabetologia, 60(8), pp. 1400-1408. (doi:10.1007/s00125-017-4297-0) (PMID:28528401) (PMCID:PMC5491560)

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Abstract

Aims/hypothesis: We investigated whether biochemical cardiovascular risk factors and/or markers of subclinical cardiovascular disease were associated with the development of reduced renal function in people with type 2 diabetes. Methods: A cohort of 1066 Scottish men and women aged 60–74 years with type 2 diabetes from the Edinburgh Type 2 Diabetes Study were followed up for a median of 6.7 years. New-onset reduced renal function was defined as two eGFRs <60 ml−1 min−1 (1.73 m)−2 at least 3 months apart with a > 25% decline from baseline eGFR. Ankle brachial pressure index (ABI), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hsTnT) were measured at baseline. Pulse wave velocity (PWV) and carotid intima media thickness were measured 1 year into follow-up. Data were analysed using Cox proportional hazards models. Results: A total of 119 participants developed reduced renal function during follow-up. ABI, PWV, NT-proBNP and hsTnT were all associated with onset of decline in renal function following adjustment for age and sex. These associations were attenuated after adjustment for additional diabetes renal disease risk factors (systolic BP, baseline eGFR, albumin:creatinine ratio and smoking pack-years), with the exception of hsTnT which remained independently associated (HR 1.51 [95% CI 1.22, 1.87]). Inclusion of hsTnT in a predictive model improved the continuous net reclassification index by 0.165 (0.008, 0.286). Conclusions/interpretation: Our findings demonstrate an association between hsTnT, a marker of subclinical cardiac ischaemia, and subsequent renal function decline. Further research is required to establish the predictive value of hsTnT and response to intervention.

Item Type:Articles
Keywords:Cardiovascular disease, chronic kidney disease, diabetic nephropathy, troponin, type 2 diabetes mellitus.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sattar, Professor Naveed
Authors: Jenks, S. J., Conway, B. R., McLachlan, S., Teoh, W. L., Williamson, R. M., Webb, D. J., Welsh, P., Sattar, N., Strachan, M. W.J., and Price, J. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Diabetologia
Publisher:Springer
ISSN:0012-186X
ISSN (Online):1432-0428
Published Online:20 May 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Diabetologia 60(8):1400-1408
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
690421Glasgow Molecular Pathology (GMP) NodeKarin OienMedical Research Council (MRC)MR/N005813/1ICS - EXPERIMENTAL THERAPEUTICS