Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection

Vimieiro, A. C. S., Araújo, N., Katz, N., Kusel, J. R. and Coelho, P. M. Z. (2013) Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection. Memorias Do Instituto Oswaldo Cruz, 108(7), pp. 881-886. (doi: 10.1590/0074-0276130135) (PMID:24271044) (PMCID:PMC3970651)

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Abstract

Mice infected with Schistosoma mansoni were treated with oxamniquine, praziquantel, artesunate at the pre-patent phase, aiming at observing schistogram alterations. Half of the animals were perfused five days post-treatment for counting and classification of immature worms, based on pre-established morphological criteria (schistogram); the remaining animals were evaluated 42 or 100 days after infection and perfusion of the portal-system was performed for collection and counting of adult worms and oogram. It was observed that oxamniquine and artesunate treatment administered at the pre-postural phase causes significant reduction in the number of immature and adult worms. However, there was little reduction with praziquantel when used at the dose of 400 mg/kg for treatments administered 14, 15, 21 or 23 days post-infection. Artesunate was responsible for significant alterations in development of young worms, as well as for a higher number of worms presenting intestinal damages. Immature adult worms were detected in mice treated with artesunate or oxamniquine at the pre-patent phase of infection and recovered by perfusion 100 days after infection. Schistogram proved to be a very useful tool for experimental evaluation of the activity of antischistosomal drugs and a good model to identify the most sensitive stages to drugs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kusel, Dr John
Authors: Vimieiro, A. C. S., Araújo, N., Katz, N., Kusel, J. R., and Coelho, P. M. Z.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Memorias Do Instituto Oswaldo Cruz
Publisher:Instituto Oswaldo Cruz
ISSN:0074-0276
First Published:First published in Memorias Do Instituto Oswaldo Cruz 108(7): 881-886
Publisher Policy:Reproduced under a Creative Commons License

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