Ultrasound capsule endoscopy: sounding out the future

Cox, B. F., Stewart, F., Lay, H. , Cummins, G., Newton, I. P., Desmulliez, M. P.Y., Steele, R. J.C., Näthke, I. and Cochran, S. (2017) Ultrasound capsule endoscopy: sounding out the future. Annals of Translational Medicine, 5(9), 201. (doi:10.21037/atm.2017.04.21) (PMID:28567381) (PMCID:PMC5438792)

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Video capsule endoscopy (VCE) has been of immense benefit in the diagnosis and management of gastrointestinal (GI) disorders since its introduction in 2001. However, it suffers from a number of well recognized deficiencies. Amongst these is the limited capability of white light imaging, which is restricted to analysis of the mucosal surface. Current capsule endoscopes are dependent on visual manifestation of disease and limited in regards to transmural imaging and detection of deeper pathology. Ultrasound capsule endoscopy (USCE) has the potential to overcome surface only imaging and provide transmural scans of the GI tract. The integration of high frequency microultrasound (µUS) into capsule endoscopy would allow high resolution transmural images and provide a means of both qualitative and quantitative assessment of the bowel wall. Quantitative ultrasound (QUS) can provide data in an objective and measurable manner, potentially reducing lengthy interpretation times by incorporation into an automated diagnostic process. The research described here is focused on the development of USCE and other complementary diagnostic and therapeutic modalities. Presently investigations have entered a preclinical phase with laboratory investigations running concurrently.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cochran, Professor Sandy and Lay, Dr Holly
Authors: Cox, B. F., Stewart, F., Lay, H., Cummins, G., Newton, I. P., Desmulliez, M. P.Y., Steele, R. J.C., Näthke, I., and Cochran, S.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Annals of Translational Medicine
Publisher:AME Publishing Company
ISSN (Online):2305-5847
Copyright Holders:Copyright © 2017 Annals of Translational Medicine
First Published:First published in Annals of Translational Medicine 5(9): 201
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
748241Sonopill: minimally invasive gastrointestinal diagnosis and therapyAlexander CochranEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/2ENG - ENGINEERING SYSTEMS POWER & ENERGY