Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection

Ribeiro, F., Mello, R. T. d., Tavares, C. A. P., Kusel, J. R. and Coelho, P. M. Z. (2004) Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection. Revista do Instituto de Medicina Tropical de São Paulo, 46(4), pp. 231-233. (doi: 10.1590/s0036-46652004000400010) (PMID:15361976)

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Abstract

The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kusel, Dr John
Authors: Ribeiro, F., Mello, R. T. d., Tavares, C. A. P., Kusel, J. R., and Coelho, P. M. Z.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Revista do Instituto de Medicina Tropical de São Paulo
Publisher:FapUNIFESP (SciELO)
ISSN:0036-4665
ISSN (Online):1678-9946
Copyright Holders:Copyright © 2004 The Authors
First Published:First published in Revista do Instituto de Medicina Tropical de São Paulo 46(4): 231-233
Publisher Policy:Reproduced under a Creative Commons License

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