MacPherson, L. and Tokatlidis, K. (2017) Protein trafficking in the mitochondrial intermembrane space: mechanisms and links to human disease. Biochemical Journal, 474(15), pp. 2533-2545. (doi: 10.1042/BCJ20160627) (PMID:28701417) (PMCID:PMC5509380)
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Abstract
Mitochondria fulfill a diverse range of functions in cells including oxygen metabolism, homeostasis of inorganic ions and execution of apoptosis. Biogenesis of mitochondria relies on protein import pathways that are ensured by dedicated multiprotein translocase complexes localized in all sub-compartments of these organelles. The key components and pathways involved in protein targeting and assembly have been characterized in great detail over the last three decades. This includes the oxidative folding machinery in the intermembrane space, which contributes to the redox-dependent control of proteostasis. Here, we focus on several components of this system and discuss recent evidence suggesting links to human proteopathy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Tokatlidis, Professor Kostas and MacPherson, Lisa |
| Authors: | MacPherson, L., and Tokatlidis, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Biochemical Journal |
| Publisher: | Portland Press |
| ISSN: | 0264-6021 |
| ISSN (Online): | 1470-8728 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Biochemical Journal 474:2533-2545 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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