Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings

Sebastiano, M., Eens, M., Abd Elgawad, H., de Thoisy, B., Lacoste, V., Pineau, K., Asard, H., Chastel, O. and Costantini, D. (2017) Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings. Scientific Reports, 7, 1599. (doi: 10.1038/s41598-017-01417-9) (PMID:28487518) (PMCID:PMC5431617)

Abstract

Infectious diseases are one of the most common threats for both domestic and wild animals, but little is known about the effects on the physiological condition and survival of wild animals. Here, we have tested for the first time in a wild vertebrate facing a viral disease possibly due to herpesvirus (i) whether nestlings with either low levels of oxidative damage or high levels of antioxidant protection are less susceptible to develop visible clinical signs, (ii) whether the disease is associated with the nestlings' oxidative status, (iii) whether the association between the disease and oxidative status is similar between males and females (iv), and whether cloacal and tracheal swabs might be used to detect herpesvirus. To address our questions, we took advantage of a population of Magnificent frigatebirds (Fregata magnificens) whose nestlings have experienced high mortality rates in recent times. Our work shows that (i) blood lipid oxidative damage is associated with observable clinical signs and survival probabilities of nestling frigatebirds, and (ii) that high glutathione levels in red blood cells are associated with the emergence of visible clinical signs of the disease. Our work provides evidence that differences in the oxidative status of nestlings might underlie individual health and survival.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Costantini, Dr David
• Authors: Sebastiano, M., Eens, M., Abd Elgawad, H., de Thoisy, B., Lacoste, V., Pineau, K., Asard, H., Chastel, O., and Costantini, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Scientific Reports
• Publisher: Nature Research
• ISSN: 2045-2322
• ISSN (Online): 2045-2322
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in Scientific Reports 7: 1599
• Publisher Policy: Reproduced under a Creative Commons License